Police were on hand as crowds gathered outside Nottingham Contemporary to welcome the newly-engaged couple.
For their first joint royal engagement, the couple, who will Wednesday next May, visited the National Justice Museum before heading off to the Nottingham Contemporary to attend the Terrence Higgins Trust charity fair, in honour of World AIDS Day, which falls on December 1.
Full Effect has been supported by The Royal Foundation of The Duke and Duchess of Cambridge and Prince Harry since 2013 and supports children and young people from the area, working to prevent youth violence and crime through intervention and mentoring.
"We're so happy for them both", Mary Cooper, 60, said.
Markle was wearing an ankle-length navy coat, as she and her fiancé greeted fans outside the National Justice Museum.
Palestinian shot dead by Israeli settler in West Bank
Several isolated hard-line settlements are in the area, situated near Palestinian villages and Nablus. Then, a group of Palestinians gathered around them, blocking them inside a cave and beating them.
The couple, who announced their engagement Monday, will spend the morning at the event, hosted by the Terrence Higgins Trust.
The soon-to-be husband and wife will go on to watch a "hip hopera" at Nottingham Academy, where they will continue to meet with students.
Anthony Devlin via Getty Images Prince Harry and Meghan Markle, Dec. 1. The American plans to become a British citizen.
It was announced earlier this week that the royal couple are set to tie the knot at St George's Chapel in the grounds of Windsor Castle in May next year.
"This is good. I'm excited to have some Americans in the royal family", USA student Mark Arnold, who is now studying at Nottingham University, told Reuters.