Syrian media reported Saturday that the "Israeli enemy fired missiles at an army base outside Damascus".
SANA, the state news agency, claimed Syrian air defenses shot down two of the Israeli missiles.
These strikes are primarily against regime targets, including a reported Israeli hit on a military research facility in early September in northwest Syria.
The Syrian Observatory for Human Rights said heavy explosions were heard in the area and electricity was cut off throughout Damascus.
The "blatant assault" led to material losses at the site in the countryside around the capital, the Syrian state media reported.
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The Israeli air force has said it struck arms convoys of the Syrian military and Lebanon's Hezbollah almost 100 times during more than six years of the Syrian war. The incident reportedly occurred Friday night, with IDF planes attacking the Iranian base at al-Kiswah, south of Damascus.
The source added that an Israeli fighter jet was flying at a low altitude over Lebanon's Baalbek region near Syria's border when the Syrian missiles were launched.
It is not clear whether the Syrian army or Iranian and Hizballah militias were targeted in the strike.
Israel has long warned that Iran is trying to establish a permanent presence in Syria. But the Prime Minister's Office saw fit to put out the short clip relating to Iranian presence in Syria on Saturday evening. The BBC published what it said were satellite images that it had commissioned that showed construction activity at the site between January and October this year.