Pochettino paid tribute to the Hull midfielder at a press conference after the draw with Juventus, saying: "It is very sad news but he opens a door for his future with his family".
Mauricio Pochettino's men will now take two away goals into the second leg at Wembley, knowing a clean sheet will secure their place in the next round of the competition.
"After going 2-0 up we stopped playing, but part of that was also down to Tottenham's performance".
The England global has netted eight goals in his previous 7 appearances for Spurs.
Tottenham face tricky opposition in Italy's most decorated club Juventus, as the Champions League knockout's get underway in Turin.
The Tottenham striker is having another excellent season and now leads the Premier League charts with 23 goals in 26 games played.
Winter Olympics 2018: Chris Mazdzer wins historic silver in men's singles luge
Loch set the tone with the first run of the day with a course record (that record was broken by Mazder moments later). Austria's David Gleirscher struggled to make the Olympic team, but is now the men's luge gold medalist.
"I should have scored the header but you have to be ready for the next one and I finished it off".
Harry Kane made Champions League history when he scored his ninth Champions League goal in as many games during Tottenham's 2-2 draw at Juventus on Tuesday night.
"It is this type of player that represents our philosophy, he's a player that links the team".
But the 30-year-old missed two further chances to hammer home Juventus's advantage in the first half, including striking the crossbar with a second penalty on the stroke of half-time. However, Higuain smashed the resulting penalty off the bar and Tottenham escaped. "The first minutes were hard but it was unbelievable how we reacted". In the last few weeks, the team are growing and have stepped up.
"Tomorrow we'll have to play an excellent match for a tactical point of view, because otherwise if we just focus on the physical aspect we could suffer a lot. But our belief, our confidence, our form are good, and we will be ready to be very competitive... we are going to be aggressive, we are going to be fearless and we are going to try to win".
Not only that but Kane's nine-goal haul from his first nine games is more than any other player in the history of Europe's blue-riband club competition - one more than the quartet of Ronaldinho, Simone Inzaghi, Didier Drogba and Diego Costa.