City have now lost their last three matches - twice against Liverpool and the defeat to Manchester United in the derby - but Guardiola said they should be proud of what they have achieved over the season with his side needing just two victories to wrap up the Premier League title.
The Reds were already the subject of UEFA disciplinary proceedings after City's team bus was attacked by supporters outside Anfield ahead of the first leg last week.
"I said he (the referee) was wrong", said Guardiola when asked about his dismissal. They've had a lot of doubters out there, questioning if they are good enough.
City are next in action with a game against Tottenham Hotspur on Saturday. When you say: 'Pep, what you have done in Barcelona or Bayern Munich, is it possible to do that without those big players?' - it's impossible, so be calm.
Perhaps that was the hint Liverpool needed to recover their confidence and whatever Klopp said to his team at half-time, there was another distinct shift which became obvious as soon as the second-half started.
Guardiola fielded an attacking lineup against Liverpool on Tuesday, with just three recognised defenders, and his approach paid off with a second minute goal from Gabriel Jesus setting up a relentless first half of attacking.
"The ball [for Sane] came from (James) Milner".
Wrestlemania 34 takeaways: Brock Lesnar's win shocks WWE Universe
It was a odd match, but brilliantly executed, leaving the fans questioning whether or not it would happen all night. These moments date back almost twenty years with some of the biggest taking place all the way back in 1998.
Guardiola marched onto the pitch at the break to remonstrate with referee Antonio Mateu Lahoz after a Leroy Sane goal that would have put his side 2-0 up was contentiously disallowed and was told to sit in the stands for the second half. I didn't insult him.
"We went from a possible 2-1 lead to 2-1 deficit". He likes to be different, he likes to be special. when everybody sees the things, he's going to decide the opposite.
Salah had been an injury doubt after limping off in the first leg, but Liverpool were unable to spring the Egyptian free in the first 45 minutes as City peppered the visitors' box with crosses without finding the final touch.
"We had many draws and they took us out of the first place".
"We had luck in a couple of moments to be honest, but when you look over the two games we have been courageous and when you are fearless the luck goes with you".