De Bruyne is one of the favourites to win the award, but the goal scoring exploits of Salah and Kane make them strong challengers for the prestigious award.
The PFA's Player of the Year will be announced on 22 April during a special awards ceremony in London.
The 45th annual PFA Awards, where the victor voted for by PFA members will be announced, is to be held in the Grosvenor House in London on April 22.
Former Manchester City defender Joleon Lescott said: 'It is hard to choose but De Bruyne pips Salah because he has helped City win the league'. He leads the assist charts with 15 and has scored 7 goals plus he played his part in winning the League Cup.
Salah meanwhile has enjoyed a sensational debut season at Liverpool.
German worldwide Sane has been directly involved in 21 goals this season for City, scoring nine times and adding a further 12 assists, which is second only to De Bruyne.
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The Spain playmaker has eight goals and 11 assists to his name in a City team which has dominated the competition this year.
Started the season on fire, but has seen his form dip in recent months, but eight assists and 16 goals is still very impressive from the former Liverpool forward.
Kane trails him by four goals in the league and three goals overall for the season, and the two are competing with one another to claim the Premier League's Golden Boot.
Of the other contenders, Tottenham's Harry Kane has banged in 25 Premier League goals this season in yet another impressive campaign.
Sane, 22, has been nominated in both Player and Young Player of the Year categories as has Kane, a victor in 2015.