Perhaps a one-on-one lesson could be in the offing at the All England Club next year, though, given how Federer keeps racking up major titles, don't expect him to explore a late-career change in sport!
This, however, is already the high point of Djokovic's year, and he knows it. Raonic never broke Isner's serve, and while Isner broke Raonic's serve just three times, it was just enough to move on.
Bethanie Mattek-Sands' return to Wimbledon won't get a ideal ending.
Federer's match point arrived when Anderson served at 4-5 in the third but, with the South African looming at the net, he made a hash of an attempted backhand pass.
In the fourth set, Federer and Anderson alternated winning the first six games until Anderson broke Federer's serve to take a 4-3 lead and then Anderson went up 5-3 thanks to strong serving before he clinched the set. One service break in the seventh game of the fourth set was then all Anderson would need to force a decider.
Next up for Anderson is a semifinal on Friday against either John Isner, the ninth seeded American. The 6-foot-8 Anderson wasn't broken in the final three sets. There is no doubt that Federer will bounce back from this quickly.
The match entered epic proportions in the fifth before Anderson sealed the decisive break at 11-11.
"In the last set there was a little of everything, great points, great rallies, he was hitting insane with his forehands".
Top seed Federer, 36, had not dropped a set on his way to the last eight. It's a match that's often won on just a couple points here and there.
He was stunned by Anderson in five sets but refused to blame his defeat on the fact he did not play on Centre.
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"It feels great to be in the last four of a Slam", Djokovic said afterwards.
The Serb looked in impressive form, particularly when he closed out the final set in ruthless fashion to set up a blockbuster semi-final with world number one Rafa Nadal.
The former Illini outlasted top-ranked Roger Federer in a marathon Wimbledon quarterfinal match on Wednesday morning, rallying to win in five sets and advance to his first-ever semifinal appearance at the All England Club. Anderson had never taken a set off Federer in the four times he had played him.
There wasn't the faintest warning that the match would turn into a cliffhanger, with Federer sauntering through the first with customary balletic ease.
Federer's forehand began to let him down, most importantly on the match point he earned at 5-4 in the third set, allowing Anderson to survive.
Defending champion Roger Federer was knocked out of Wimbledon after South Africa's Kevin Anderson roared back from two sets down to win a thrilling quarter-final clash on Wednesday.
Swiss great Roger Federer exits the 2018 Wimbledon Championships earlier than expected. He is now 266-3 when leading 2-0. Maybe it was the unfamiliar surroundings of Court No 1 - he had played all his previous matches this year on Centre Court.
The 20-time Grand Slam champion appeared to be moving towards his 5th successive Wimbledon semifinal after taking the opening two sets.
Three-time champion Novak Djokovic has opened proceedings on Centre Court against 24th-seeded Kei Nishikori. He had lost 6-3, 7-6 (3), 4-6, 4-6, 4-6 to Jo-Wilfried Tsonga in the quarter-finals at Wimbledon in 2011 and then 7-6 (7), 6-4, 3-6, 2-6, 5-7 to Novak Djokovic at the US Open the same year.
Federer battled back from 0-3 down to force a tie-break, where Anderson grabbed a 2-0 head-start. It was just one of those days where you hope to get by somehow. It's just the third time he's lost a major match after being up two sets to none. He had showed some vulnerability in losing the Indian Wells final to Juan Martin del Potro and the final in Halle, his playground, to youngster Borna Coric.