"I think there is often a mistaken assumption that possession leads to goal-scoring opportunities", said the former coach of Cagliari and AC Milan.
Cristiano Ronaldo and Lionel Messi look dejected after their respective Round of 16 matches.
It was Edinson Cavani who instead took the spotlight.
The Iberians moved the ball quicker after the break and they were rewarded with an equaliser in the 55th minute. With that said, Rodrigo Bentancur soon restored the advantage as he laid on the second for Cavani.
"It's exciting. there are no words to describe this".
Guerreiro fired over from the edge of the box after a corner had fallen to him, and then Ronaldo laid the ball back to Adrien Silva, whose shot was deflected behind for a 55th-minute corner.
Sampaoli: No decision on Argentina's starting XI for France clash
Argentina could stick with the same team that defeated Nigeria on Tuesday night. "Now, I see him a lot more comfortable now". The Barcelona star is heating up, scoring his first goal of the 2018 World Cup against Nigeria in his squad's last match.
Uruguay's Edinson Cavani scores his side's opening goal.
Uruguay won all three of their group matches, beating hosts Russian Federation 3-0 in their last outing, and are the only team yet to concede a goal at the tournament.
Up next? A place in the World Cup quarter-finals is at stake as Uruguay and Portugal face off in the last 16 this evening.
Given their ages - Messi is 31 and Ronaldo 33 - this could be the last the world sees of the pair, who have monopolised the world player of the year award for the last 10 years, on the biggest stage of all.
The result sends the European team out of the World Cup, however many were taken aback by how little impact Ronaldo was able to have on the match.
Uruguay were ahead as early as the seventh minute when Cavani and Luis Suarez exchanged passes from one end of the pitch to the other.
How Godin and Gimenez fare against Ronaldo is one of the intriguing subplots surrounding this fixture, though both sides' defensive records have some fearing a tiresome contest.
But they were level for just seven minutes as Cavani swept home a sensational victor. "We have a team with many young players in it and of course we all want him there with us".
It was a five-pass buildup from deep in their own end that culminated in Uruguay's first goal, and the final two passes were ideal. Just a few steps inside Portugal's half, Cavani hit Suarez with a pinpoint cross over the top of the back line, and immediately made a run behind the Portuguese defense.