However Ronaldo, who will be 37 by the time of the next World Cup, would not be drawn on whether he planned to extend his global career. The matchup pits Group A victor Uruguay against Group B runner-up Portugal in a game star power might decide. "But you always want to win, and we lost, so well done to Uruguay for making it through".
Ronaldo nearly had a chance at goal on 20 minutes but a timely clearance by Gimenez six yards was enough to keep Ronaldo at bay.
Uruguay will play France in their quarter-final on Friday.
And just like that, he joined Messi in heading out of Russian Federation and out of the World Cup. Ronaldo ran in front of Pepe and drew the attention of both Gimenez and Godin.
Ronaldo struggled for consistent touches in advanced areas, and was often forced into cutting inside and letting fly from range, which more often than not saw his shot cannon off the nearest defender and back the other way.
Portugal would have to wait for the second half to equalise - with a goal in the 55th minute from Pepe. Star player Luis Suarez scored twice as Uruguay defeated Egypt, Saudi Arabia and hosts Russian Federation to set up a Round of 16 tie with reigning European champions, Portugal.
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Martin Caceres and Nahitan Nandez combined to create a chance but the move ended when Cavani was unable to control an awkwardly-bouncing ball, and with five minutes remaining until the break Joao Mario made a promising run down the left only to slip.
Uruguay will be sweating on Cavani's fitness for the next round after he left the match midway through the second half with an injury, though.
And he managed to score a-not-too-shabby four games in the tournament.
Cavani responded in style, though, and found the corner of the net with a composed finish from the edge of the box to send Uruguay into the quarter-finals.
Attention will now turn to whether Ronaldo will continue to captain Portugal but the 33-year-old stated that those questions are for another day.
Suarez could have put Uruguay 2-0 ahead in the 22nd minute as a diving Patricio parried clear a low free-kick which went under the Portuguese jumping wall towards the bottom right.