She has made it to the final four at three of the past five Grand Slam tournaments but is still seeking her first major championship. Who will come out on top?
Sevastova stunned Williams in the first game of the match, staying consistent and calm while leading the American into miscues, causing Williams to drop serve. But in terms of experience the clear advantage lies with Williams.
Particular praise was heaped on 20-year-old Osaka, who became the first Japanese woman to get into the top four at the US Open. Sevastova, as mentioned above, is competing in her first.
The Japanese sputtered along until earning his first break chance at 2-4 in the second set and was able to convert to get back on serve. Much like her hard-hitting contemporaries such as Petra Kvitova, she's untouchable at her best but prone to eyebrow-raising losses on a bad day. She was tested by Kaia Kanepi, however, in the fourth round but advanced a 6-0 4-6 6-3 victor before brushing aside Karolina Pliskova 6-4 6-3.
As the lingering jitters that have dogged Serena Williams at various points of her otherwise impressive comeback fade, she is re-establishing the aura that has already put her one clear of Steffi Graf's 22 grand-slam titles and one short of the all-time record set by Margaret Court.
Osaka beat her opponent Lesia Tsurenko 6-1, 6-1. With Suarez Navarro serving, the Spaniard took a 30-0 lead, but after a service error allowed Keys back in, she fought back to win a second set point and take the set, 6-4.
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How do they match up?
"She has taken a step into uncharted territory for Japanese women in NY", the paper added.
As Osaka has climbed the ranks in women's tennis, her identity has been the subject of curiosity for many tennis fans.
Tsurenko, the only unseeded woman to reach this stage of the tournament, appeared to be feeling the effects of her last-16 clash during which she struggled in the searing heat and at one point looked like she was about to collapse. I think I probably have a little bit more spin on the ball, but I think she takes time away really well.
For Williams, it was more of what we've seen all Open.
She immediately lost her serve but then broke back to level at 2-2 after the Latvian's clever dropshots began to misfire.